Urokinase- and Tissue-Type Plasminogen Activators in Keratinocytes During Wound Reepithelialization In Vivo
نویسندگان
چکیده
منابع مشابه
Mouse neural crest cells secrete both urokinase-type and tissue-type plasminogen activators in vitro.
Neural tubes of E8-5 day mouse embryos were dissected and cultured in serum substitute-supplemented medium to allow the emigration of neural crest cells. After 48 h of culture the neural tubes were removed. The neural crest cells were then cultured for 12 h in serum-free medium, and their culture supernatant was studied by electrophoresis and zymography. The cultured cells were shown to secrete...
متن کاملPlasminogen activators in alcoholic cirrhosis: demonstration of increased tissue type and urokinase type activator.
Plasma samples from patients with alcoholic cirrhosis were analysed for plasminogen activators and for inhibitors of the fibrinolytic system. Plasminogen activator activity was considerably increased in patients' plasma compared with normal. Immunochemical characterisation of these plasminogen activators showed that they included both tissue type and urokinase type plasminogen activator. The ma...
متن کاملThrombolytic and pharmacokinetic properties of chimeric tissue-type and urokinase-type plasminogen activators.
BACKGROUND Chimeric molecules comprising the A-chain of tissue-type plasminogen activator (t-PA) and the catalytic domain of urokinase-type plasminogen activator (u-PA) have intact enzymatic characteristics of u-PA, partial fibrin-binding properties of t-PA, and thrombolytic properties in animal models comparable with but not superior to those of single-chain u-PA (scu-PA). Deletion of the fing...
متن کاملSites of synthesis of urokinase and tissue-type plasminogen activators in the murine kidney.
Kidneys have long been recognized as a major source of plasminogen activators (PAs). However, neither the sites of synthesis of the enzymes nor their role in renal function have been elucidated. By the combined use of zymographies on tissue sections and in situ hybridizations, we have explored the cellular distribution of urokinase-type (u-PA) and tissue-type (t-PA) plasminogen activators and o...
متن کاملUrokinase-type plasminogen activator and plasminogen mediate activation of macrophage phagocytosis during liver repair in vivo.
Urokinase-type plasminogen activator (u-PA) and plasminogen play a primary role in liver repair through the accumulation of macrophages and alteration of their phenotype. However, it is still unclear whether u-PA and plasminogen mediate the activation of macrophage phagocytosis during liver repair. Herein, we investigated the morphological changes in macrophages that accumulated at the edge of ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1988
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12461511